S Illinois
Southern Illinois Salukis · Carbondale, IL
Missouri Valley Football Conference · FCS
All teams · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/3 | A | Incarnate Word (10-1) | [FCS:LAND] | L | 29-64 | |
| 9/10 | H | SE Missouri (9-2) | [FCS:OVC] | L | 31-34 | |
| 9/17 | A | Northwestern (1-11) | [P4:Big Ten] | W | 31-24 | |
| 9/24 | H | North Dakota (7-4) | [FCS:MVFC] | W | 34-17 | |
| 10/1 | A | Illinois St (6-5) | [FCS:MVFC] | W | 19-14 | |
| 10/8 | A | Missouri St (5-6) | [FCS:MVFC] | W | 38-21 | |
| 10/15 | H | W Illinois (0-11) | [FCS:MVFC] | W | 30-7 | |
| 10/22 | A | South Dakota (3-8) | [FCS:MVFC] | L | 24-27 | |
| 10/29 | H | Northern Iowa (6-5) | [FCS:MVFC] | L | 36-37 | |
| 11/12 | H | N Dakota St (9-2) | [FCS:MVFC] | L | 18-21 | |
| 11/19 | A | Youngstown St (7-4) | [FCS:MVFC] | L | 21-28 |