S Illinois
Southern Illinois Salukis · Carbondale, IL
Missouri Valley Football Conference · FCS
All teams · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 8/30 | H | Thomas More | [Lower] | W | 49-3 | |
| 9/6 | A | Purdue (2-10) | [P4:Big Ten] | L | 17-34 | |
| 9/13 | A | UT Martin (6-6) | [FCS:OVC] | W | 37-10 | |
| 9/20 | A | SE Missouri (4-8) | [FCS:OVC] | W | 59-31 | |
| 10/4 | H | Indiana St (3-9) | [FCS:MVFC] | W | 55-27 | |
| 10/11 | A | N Dakota St (12-0) | [FCS:MVFC] | L | 17-45 | |
| 10/18 | H | North Dakota (7-5) | [FCS:MVFC] | L | 19-38 | |
| 10/25 | H | Northern Iowa (3-9) | [FCS:MVFC] | W | 31-17 | |
| 11/1 | A | Murray St (1-11) | [FCS:MVFC] | W | 27-7 | |
| 11/8 | A | Youngstown St (8-4) | [FCS:MVFC] | L | 38-48 | |
| 11/15 | H | South Dakota (8-4) | [FCS:MVFC] | L | 51-53 | |
| 11/22 | A | Illinois St (8-4) | [FCS:MVFC] | W | 37-7 |