S Illinois
Southern Illinois Salukis · Carbondale, IL
Missouri Valley Football Conference · FCS
All teams · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 8/31 | A | BYU (10-2) | [P4:Big 12] | L | 13-41 | |
| 9/7 | A | Austin Peay (4-8) | [FCS:UAC] | W | 31-17 | |
| 9/14 | H | Incarnate Word (10-2) | [FCS:LAND] | W | 35-28 | |
| 9/21 | H | SE Missouri (9-3) | [FCS:OVC] | L | 21-38 | |
| 9/28 | A | South Dakota (9-2) | [FCS:MVFC] | L | 13-42 | |
| 10/5 | H | Illinois St (9-3) | [FCS:MVFC] | L | 10-45 | |
| 10/12 | H | N Dakota St (10-2) | [FCS:MVFC] | L | 3-24 | |
| 10/26 | A | Indiana St (4-8) | [FCS:MVFC] | L | 17-20 | |
| 11/2 | A | Missouri St (8-4) | [FCS:MVFC] | L | 17-38 | |
| 11/9 | H | Youngstown St (4-8) | [FCS:MVFC] | W | 37-33 | |
| 11/16 | A | S Dakota St (10-2) | [FCS:MVFC] | L | 10-41 | |
| 11/23 | H | Murray St (1-11) | [FCS:MVFC] | W | 62-0 |