S Illinois
Southern Illinois Salukis · Carbondale, IL
Missouri Valley Football Conference · FCS
All teams · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/5 | A | Indiana (6-6) | [P4:Big Ten] | L | 47-48 | |
| 9/12 | A | SE Missouri (4-7) | [FCS:OVC] | L | 24-27 | |
| 9/26 | H | Liberty (6-5) | [FCS:BSOU] | W | 34-13 | |
| 10/3 | A | W Illinois (6-5) | [FCS:MVFC] | L | 36-37 | |
| 10/10 | H | Missouri St (1-10) | [FCS:MVFC] | W | 73-26 | |
| 10/17 | A | Indiana St (5-6) | [FCS:MVFC] | L | 36-39 | |
| 10/24 | H | Youngstown St (5-6) | [FCS:MVFC] | W | 38-31 | |
| 10/31 | H | N Dakota St (9-2) | [FCS:MVFC] | L | 29-35 | |
| 11/7 | A | South Dakota (5-6) | [FCS:MVFC] | L | 31-34 | |
| 11/14 | H | Illinois St (9-2) | [FCS:MVFC] | L | 21-42 | |
| 11/21 | A | Northern Iowa (7-4) | [FCS:MVFC] | L | 28-49 |