S Illinois
Southern Illinois Salukis ·
Missouri Valley Football Conference · FCS
All teams · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/8 | A | SE Missouri (4-6) | [FCS:OVC] | L | 5-24 | |
| 9/15 | A | Ball State (5-6) | [G5:MAC] | canceled | ||
| 9/22 | H | Murray St (4-6) | [FCS:OVC] | L | 20-24 | |
| 9/29 | A | W Illinois (5-5) | [FCS:MVFC] | L | 21-38 | |
| 10/6 | H | Illinois St (2-9) | [FCS:MVFC] | W | 23-17 | |
| 10/13 | A | Northern Iowa (11-3) | [FCS:MVFC] | L | 14-19 | |
| 10/20 | H | E Illinois (9-2) | [FCS:OVC] | L | 21-49 | |
| 10/27 | A | Indiana St (3-8) | [FCS:MVFC] | L | 14-20 | |
| 11/3 | H | Youngstown St (8-3) | [FCS:MVFC] | L | 7-31 | |
| 11/10 | H | Missouri St (5-5) | [FCS:MVFC] | L | 24-25 | |
| 11/17 | A | Western KY (8-4) | [FCS:MVFC] | L | 6-36 | |
| 11/24 | A | Baylor (3-8) | [P4:Big 12] | L | 12-56 |