S Illinois
Southern Illinois Salukis ·
Missouri Valley Football Conference · FCS
All teams · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 8/29 | H | Kentucky Wesleyan | [Lower] | W | 78-0 | |
| 9/7 | H | SE Missouri (8-4) | [FCS:OVC] | L | 14-21 | |
| 9/14 | A | Murray St (7-5) | [FCS:OVC] | L | 24-42 | |
| 9/21 | H | W Virginia Tech | [Lower] | W | 76-21 | |
| 9/28 | A | E Michigan (3-9) | [G5:MAC] | L | 45-48 | |
| 10/5 | H | W Illinois (11-2) | [FCS:MVFC] | W | 54-52 | |
| 10/12 | H | Northern Iowa (5-6) | [FCS:MVFC] | W | 42-13 | |
| 10/19 | A | Illinois St (6-5) | [FCS:MVFC] | L | 14-35 | |
| 10/26 | A | Missouri St (4-7) | [FCS:MVFC] | L | 28-38 | |
| 11/2 | A | Youngstown St (7-4) | [FCS:MVFC] | L | 9-21 | |
| 11/9 | H | Indiana St (5-7) | [FCS:MVFC] | L | 14-21 | |
| 11/16 | H | Western KY (10-3) | [FCS:MVFC] | L | 16-48 |