S Illinois
Southern Illinois Salukis · Carbondale, IL
Missouri Valley Football Conference · FCS
All teams · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/9 | H | Miss Valley St (2-9) | [FCS:SWAC] | W | 55-3 | |
| 9/16 | A | SE Missouri (3-8) | [FCS:OVC] | W | 35-17 | |
| 9/23 | A | Memphis (10-2) | [G5:AAC] | L | 31-44 | |
| 9/30 | H | Northern Iowa (7-4) | [FCS:MVFC] | L | 17-24 | |
| 10/7 | A | S Dakota St (9-2) | [FCS:MVFC] | L | 14-49 | |
| 10/14 | H | Illinois St (6-5) | [FCS:MVFC] | W | 42-7 | |
| 10/21 | A | Indiana St (0-11) | [FCS:MVFC] | W | 45-24 | |
| 10/28 | A | South Dakota (7-4) | [FCS:MVFC] | L | 0-42 | |
| 11/4 | H | Missouri St (3-8) | [FCS:MVFC] | L | 28-36 | |
| 11/11 | H | Youngstown St (6-5) | [FCS:MVFC] | L | 20-28 | |
| 11/18 | A | W Illinois (8-3) | [FCS:MVFC] | L | 14-28 |