S Illinois
Southern Illinois Salukis · Carbondale, IL
Missouri Valley Football Conference · FCS
All teams · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/3 | A | FAU (3-9) | [G5:CUSA] | L | 30-38 | |
| 9/10 | H | SE Missouri (3-8) | [FCS:OVC] | W | 30-22 | |
| 9/17 | H | Murray St (4-7) | [FCS:OVC] | W | 50-17 | |
| 10/1 | A | Northern Iowa (5-6) | [FCS:MVFC] | L | 21-42 | |
| 10/8 | H | S Dakota St (8-3) | [FCS:MVFC] | L | 39-45 | |
| 10/15 | A | Illinois St (6-5) | [FCS:MVFC] | L | 28-31 | |
| 10/22 | H | Indiana St (4-7) | [FCS:MVFC] | L | 14-22 | |
| 10/29 | A | Missouri St (4-7) | [FCS:MVFC] | L | 35-38 | |
| 11/5 | H | South Dakota (4-7) | [FCS:MVFC] | W | 35-28 | |
| 11/12 | A | Youngstown St (8-3) | [FCS:MVFC] | L | 14-21 | |
| 11/19 | H | W Illinois (6-5) | [FCS:MVFC] | W | 44-34 |