S Illinois
Southern Illinois Salukis · Carbondale, IL
Missouri Valley Football Conference · FCS
All teams · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 8/27 | A | West Florida (3-2) | [FCS:UAC] | L | 31-34 | |
| 9/3 | A | Samford (1-5) | [FCS:SOUTH] | W | 22-18 | |
| 9/12 | H | SE Missouri (3-3) | [FCS:OVC] | W | 34-20 | |
| 9/19 | A | Illinois (3-3) | [P4:Big Ten] | L | 10-48 | |
| 9/26 | A | Murray St (1-5) | [FCS:MVFC] | W | 46-6 | |
| 10/3 | H | Youngstown St (5-2) | [FCS:MVFC] | L | 16-28 | |
| 10/10 | A | South Dakota (5-2) | [FCS:MVFC] | L | 10-31 | |
| 10/17 | H | Illinois St (4-2) | [FCS:MVFC] | |||
| 10/24 | H | Northern Iowa (3-2) | [FCS:MVFC] | |||
| 11/7 | A | Indiana St (2-5) | [FCS:MVFC] | |||
| 11/14 | H | S Dakota St (5-1) | [FCS:MVFC] | |||
| 11/21 | A | North Dakota (5-2) | [FCS:MVFC] |