S Illinois
Southern Illinois Salukis · Carbondale, IL
Missouri Valley Football Conference · FCS
All teams · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 8/30 | A | Murray St (5-6) | [FCS:OVC] | W | 49-10 | |
| 9/8 | A | Ole Miss (5-7) | [P4:SEC] | L | 41-76 | |
| 9/15 | H | SE Missouri (8-3) | [FCS:OVC] | L | 44-48 | |
| 9/29 | H | South Dakota (4-7) | [FCS:MVFC] | L | 24-31 | |
| 10/6 | A | Youngstown St (4-7) | [FCS:MVFC] | L | 14-17 | |
| 10/13 | A | Illinois St (6-5) | [FCS:MVFC] | L | 3-51 | |
| 10/20 | H | Indiana St (7-4) | [FCS:MVFC] | L | 21-24 | |
| 10/27 | A | Missouri St (4-7) | [FCS:MVFC] | W | 49-35 | |
| 11/3 | H | W Illinois (5-6) | [FCS:MVFC] | L | 31-34 | |
| 11/10 | H | S Dakota St (8-2) | [FCS:MVFC] | L | 38-57 | |
| 11/17 | A | N Dakota St (11-0) | [FCS:MVFC] | L | 17-65 |