S Illinois
Southern Illinois Salukis · Carbondale, IL
Missouri Valley Football Conference · FCS
All teams · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/2 | H | Quincy | [Lower] | W | 70-7 | |
| 9/11 | A | Illinois (6-6) | [P4:Big Ten] | L | 3-35 | |
| 9/18 | H | SE Missouri (9-2) | [FCS:OVC] | L | 21-24 | |
| 9/25 | A | Youngstown St (3-8) | [FCS:MVFC] | L | 28-31 | |
| 10/2 | A | Illinois St (6-5) | [FCS:MVFC] | W | 38-17 | |
| 10/9 | H | Northern Iowa (7-4) | [FCS:MVFC] | W | 45-38 | |
| 10/16 | H | S Dakota St (5-6) | [FCS:MVFC] | L | 10-31 | |
| 10/30 | A | Missouri St (5-6) | [FCS:MVFC] | L | 41-51 | |
| 11/6 | A | N Dakota St (7-4) | [FCS:MVFC] | L | 6-20 | |
| 11/13 | H | W Illinois (7-4) | [FCS:MVFC] | W | 20-10 | |
| 11/20 | H | Indiana St (6-5) | [FCS:MVFC] | W | 49-21 |