Big Ten rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/2 | H | Toledo (11-2) | [G5:MAC] | W | 30-28 | |
| 9/8 | A | Kansas (8-4) | [P4:Big 12] | L | 23-34 | |
| 9/16 | H | Penn State (10-2) | [P4:Big Ten] | L | 13-30 | |
| 9/23 | H | FAU (4-8) | [G5:AAC] | W | 23-17 | |
| 9/30 | A | Purdue (4-8) | [P4:Big Ten] | L | 19-44 | |
| 10/6 | H | Nebraska (5-7) | [P4:Big Ten] | L | 7-20 | |
| 10/14 | A | Maryland (7-5) | [P4:Big Ten] | W | 27-24 | |
| 10/21 | H | Wisconsin (7-5) | [P4:Big Ten] | L | 21-25 | |
| 11/4 | A | Minnesota (5-7) | [P4:Big Ten] | W | 27-26 | |
| 11/11 | H | Indiana (3-9) | [P4:Big Ten] | W | 48-45 | |
| 11/18 | A | Iowa (10-3) | [P4:Big Ten] | L | 13-15 | |
| 11/25 | H | Northwestern (7-5) | [P4:Big Ten] | L | 43-45 |