Big Ten rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 8/30 | N | Missouri (9-4) | [P4:Big 12] | L | 42-52 | STATE FARM ARCH RIVALRY GAME |
| 9/6 | H | E Illinois (5-7) | [FCS:OVC] | W | 47-21 | |
| 9/13 | H | Louisiana (6-6) | [G5:Sun Belt] | W | 20-17 | |
| 9/27 | A | Penn State (11-1) | [P4:Big Ten] | L | 24-38 | |
| 10/4 | A | Michigan (3-9) | [P4:Big Ten] | W | 45-20 | |
| 10/11 | H | Minnesota (7-5) | [P4:Big Ten] | L | 20-27 | |
| 10/18 | H | Indiana (3-9) | [P4:Big Ten] | W | 55-13 | |
| 10/25 | A | Wisconsin (7-5) | [P4:Big Ten] | L | 17-27 | |
| 11/1 | H | Iowa (8-4) | [P4:Big Ten] | W | 27-24 | |
| 11/8 | A | W Michigan (9-3) | [G5:MAC] | L | 17-23 | AT DETROIT MI |
| 11/15 | H | Ohio State (10-2) | [P4:Big Ten] | L | 20-30 | |
| 11/22 | A | Northwestern (9-3) | [P4:Big Ten] | L | 10-27 |