Big Ten rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/2 | H | Ball State (2-10) | [G5:MAC] | W | 24-21 | |
| 9/9 | H | Western KY (6-6) | [G5:CUSA] | W | 20-7 | |
| 9/15 | A | South Florida (9-2) | [G5:AAC] | L | 23-47 | |
| 9/29 | H | Nebraska (4-8) | [P4:Big Ten] | L | 6-28 | |
| 10/7 | A | Iowa (7-5) | [P4:Big Ten] | L | 16-45 | |
| 10/14 | H | Rutgers (4-8) | [P4:Big Ten] | L | 24-35 | |
| 10/21 | A | Minnesota (5-7) | [P4:Big Ten] | L | 17-24 | |
| 10/28 | H | Wisconsin (12-1) | [P4:Big Ten] | L | 10-24 | |
| 11/4 | A | Purdue (6-6) | [P4:Big Ten] | L | 10-29 | |
| 11/11 | H | Indiana (5-7) | [P4:Big Ten] | L | 14-24 | |
| 11/18 | A | Ohio State (11-2) | [P4:Big Ten] | L | 14-52 | |
| 11/25 | H | Northwestern (9-3) | [P4:Big Ten] | L | 7-42 |