Big Ten rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/5 | H | Kent State (3-9) | [G5:MAC] | W | 52-3 | |
| 9/12 | H | W Illinois (6-5) | [FCS:MVFC] | W | 44-0 | |
| 9/19 | A | North Carolina (11-2) | [P4:ACC] | L | 14-48 | |
| 9/26 | H | MTSU (7-5) | [G5:CUSA] | W | 27-25 | |
| 10/3 | H | Nebraska (5-7) | [P4:Big Ten] | W | 14-13 | |
| 10/10 | A | Iowa (12-1) | [P4:Big Ten] | L | 20-29 | |
| 10/24 | H | Wisconsin (9-3) | [P4:Big Ten] | L | 13-24 | |
| 10/31 | A | Penn State (7-5) | [P4:Big Ten] | L | 0-39 | |
| 11/7 | A | Purdue (2-10) | [P4:Big Ten] | W | 48-14 | |
| 11/14 | H | Ohio State (11-1) | [P4:Big Ten] | L | 3-28 | |
| 11/21 | A | Minnesota (5-7) | [P4:Big Ten] | L | 23-32 | |
| 11/28 | N | Northwestern (10-2) | [P4:Big Ten] | L | 14-24 |