Big Ten rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/1 | H | Kent State (2-10) | [G5:MAC] | W | 31-24 | |
| 9/8 | H | W Illinois (5-6) | [FCS:MVFC] | W | 34-14 | |
| 9/15 | N | South Florida (7-5) | [G5:AAC] | L | 19-25 | |
| 9/21 | H | Penn State (9-3) | [P4:Big Ten] | L | 24-63 | |
| 10/6 | A | Rutgers (1-11) | [P4:Big Ten] | W | 38-17 | |
| 10/13 | H | Purdue (6-6) | [P4:Big Ten] | L | 7-46 | |
| 10/20 | A | Wisconsin (7-5) | [P4:Big Ten] | L | 20-49 | |
| 10/27 | A | Maryland (5-7) | [P4:Big Ten] | L | 33-63 | |
| 11/3 | H | Minnesota (6-6) | [P4:Big Ten] | W | 55-31 | |
| 11/10 | A | Nebraska (4-8) | [P4:Big Ten] | L | 35-54 | |
| 11/17 | H | Iowa (8-4) | [P4:Big Ten] | L | 0-63 | |
| 11/24 | A | Northwestern (8-5) | [P4:Big Ten] | L | 16-24 |