Big Ten rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/5 | N | Missouri (8-4) | [P4:Big 12] | L | 9-37 | AT ST LOUIS MO |
| 9/12 | H | Illinois St (6-5) | [FCS:MVFC] | W | 45-17 | |
| 9/26 | A | Ohio State (10-2) | [P4:Big Ten] | L | 0-30 | |
| 10/3 | H | Penn State (10-2) | [P4:Big Ten] | L | 17-35 | |
| 10/10 | H | Michigan St (6-6) | [P4:Big Ten] | L | 14-24 | |
| 10/17 | A | Indiana (4-8) | [P4:Big Ten] | L | 14-27 | |
| 10/24 | A | Purdue (5-7) | [P4:Big Ten] | L | 14-24 | |
| 10/31 | H | Michigan (5-7) | [P4:Big Ten] | W | 38-13 | |
| 11/7 | A | Minnesota (6-6) | [P4:Big Ten] | W | 35-32 | |
| 11/14 | H | Northwestern (8-4) | [P4:Big Ten] | L | 16-21 | |
| 11/27 | A | Cincinnati (12-0) | [P4:Big East] | L | 36-49 | |
| 12/5 | H | Fresno St (8-4) | [G5:WAC] | L | 52-53 |