Big Ten rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/2 | H | Ohio State (11-1) | [P4:Big Ten] | L | 3-23 | |
| 9/8 | H | Indiana St (1-10) | [FCS:MVFC] | W | 41-7 | |
| 9/16 | N | Louisville (10-3) | [P4:ACC] | L | 14-21 | |
| 9/23 | H | Akron (2-10) | [G5:MAC] | W | 29-27 | |
| 9/30 | A | Maryland (7-5) | [P4:Big Ten] | L | 17-44 | |
| 10/14 | A | Michigan (13-0) | [P4:Big Ten] | L | 7-52 | |
| 10/21 | H | Rutgers (6-6) | [P4:Big Ten] | L | 14-31 | |
| 10/28 | A | Penn State (10-2) | [P4:Big Ten] | L | 24-33 | |
| 11/4 | H | Wisconsin (7-5) | [P4:Big Ten] | W | 20-14 | |
| 11/11 | A | Illinois (5-7) | [P4:Big Ten] | L | 45-48 | |
| 11/18 | H | Michigan St (4-8) | [P4:Big Ten] | L | 21-24 | |
| 11/25 | A | Purdue (4-8) | [P4:Big Ten] | L | 31-35 |