Big 12 rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/1 | H | Nicholls (8-3) | [FCS:LAND] | L | 23-26 | |
| 9/8 | A | C Michigan (1-11) | [G5:MAC] | W | 31-7 | |
| 9/15 | H | Rutgers (1-11) | [P4:Big Ten] | W | 55-14 | |
| 9/22 | A | Baylor (6-6) | [P4:Big 12] | L | 7-26 | |
| 9/29 | H | Oklahoma St (6-6) | [P4:Big 12] | L | 28-48 | |
| 10/6 | A | West Virginia (8-3) | [P4:Big 12] | L | 22-38 | |
| 10/20 | A | Texas Tech (5-7) | [P4:Big 12] | L | 16-48 | |
| 10/27 | H | TCU (6-6) | [P4:Big 12] | W | 27-26 | |
| 11/3 | H | Iowa State (8-4) | [P4:Big 12] | L | 3-27 | |
| 11/10 | A | Kansas St (5-7) | [P4:Big 12] | L | 17-21 | |
| 11/17 | A | Oklahoma (12-1) | [P4:Big 12] | L | 40-55 | |
| 11/23 | H | Texas (9-4) | [P4:Big 12] | L | 17-24 |