Big 12 rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/1 | N | Ole Miss (5-7) | [P4:SEC] | L | 27-47 | ADVOCARE TEXAS KICKOFF |
| 9/8 | H | Lamar (7-4) | [FCS:LAND] | W | 77-0 | |
| 9/15 | H | Houston (8-4) | [G5:AAC] | W | 63-49 | |
| 9/22 | A | Oklahoma St (6-6) | [P4:Big 12] | W | 41-17 | |
| 9/29 | H | West Virginia (8-3) | [P4:Big 12] | L | 34-42 | |
| 10/11 | A | TCU (6-6) | [P4:Big 12] | W | 17-14 | |
| 10/20 | H | Kansas (3-9) | [P4:Big 12] | W | 48-16 | |
| 10/27 | A | Iowa State (8-4) | [P4:Big 12] | L | 31-40 | |
| 11/3 | H | Oklahoma (12-1) | [P4:Big 12] | L | 46-51 | |
| 11/10 | H | Texas (9-4) | [P4:Big 12] | L | 34-41 | |
| 11/17 | A | Kansas St (5-7) | [P4:Big 12] | L | 6-21 | |
| 11/24 | N | Baylor (6-6) | [P4:Big 12] | L | 24-35 |