Big 12 rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/3 | H | McNeese (6-5) | [FCS:LAND] | W | 42-24 | |
| 9/10 | H | N Illinois (10-3) | [G5:MAC] | W | 45-42 | |
| 9/17 | A | Georgia Tech (8-4) | [P4:ACC] | L | 24-66 | |
| 10/1 | H | Texas Tech (5-7) | [P4:Big 12] | L | 34-45 | |
| 10/8 | A | Oklahoma St (11-1) | [P4:Big 12] | L | 28-70 | |
| 10/15 | H | Oklahoma (9-3) | [P4:Big 12] | L | 17-47 | |
| 10/22 | H | Kansas St (10-2) | [P4:Big 12] | L | 21-59 | |
| 10/29 | A | Texas (7-5) | [P4:Big 12] | L | 0-43 | |
| 11/5 | A | Iowa State (6-6) | [P4:Big 12] | L | 10-13 | |
| 11/12 | H | Baylor (9-3) | [P4:Big 12] | L | 30-31 | |
| 11/19 | A | Texas A&M (6-6) | [P4:Big 12] | L | 7-61 | |
| 11/26 | N | Missouri (7-5) | [P4:Big 12] | L | 10-24 | AT KANSAS CITY MO |