Big 12 rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/3 | H | Rhode Island (2-9) | [FCS:CAA] | W | 55-6 | |
| 9/10 | H | Ohio (8-5) | [G5:MAC] | L | 21-37 | |
| 9/17 | A | Memphis (8-4) | [G5:AAC] | L | 7-43 | |
| 9/29 | A | Texas Tech (5-7) | [P4:Big 12] | L | 19-55 | |
| 10/8 | H | TCU (6-6) | [P4:Big 12] | L | 23-24 | |
| 10/15 | A | Baylor (6-6) | [P4:Big 12] | L | 7-49 | |
| 10/22 | H | Oklahoma St (9-3) | [P4:Big 12] | L | 20-44 | |
| 10/29 | A | Oklahoma (10-2) | [P4:Big 12] | L | 3-56 | |
| 11/5 | A | West Virginia (10-2) | [P4:Big 12] | L | 21-48 | |
| 11/12 | H | Iowa State (3-9) | [P4:Big 12] | L | 24-31 | |
| 11/19 | H | Texas (5-7) | [P4:Big 12] | W | 24-21 | |
| 11/26 | A | Kansas St (8-4) | [P4:Big 12] | L | 19-34 |