Big 12 rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/4 | H | N Dakota St (7-4) | [FCS:MVFC] | L | 3-6 | |
| 9/11 | H | Georgia Tech (6-6) | [P4:ACC] | W | 28-25 | |
| 9/17 | A | Southern Miss (8-4) | [G5:CUSA] | L | 16-31 | |
| 9/25 | H | New Mexico St (2-10) | [G5:WAC] | W | 42-16 | |
| 10/2 | A | Baylor (7-5) | [P4:Big 12] | L | 7-55 | |
| 10/14 | H | Kansas St (7-5) | [P4:Big 12] | L | 7-59 | |
| 10/23 | H | Texas A&M (9-3) | [P4:Big 12] | L | 10-45 | |
| 10/30 | A | Iowa State (5-7) | [P4:Big 12] | L | 16-28 | |
| 11/6 | H | Colorado (5-7) | [P4:Big 12] | W | 52-45 | |
| 11/13 | A | Nebraska (10-3) | [P4:Big 12] | L | 3-20 | |
| 11/20 | H | Oklahoma St (10-2) | [P4:Big 12] | L | 14-48 | |
| 11/27 | N | Missouri (10-2) | [P4:Big 12] | L | 7-35 | AT KANSAS CITY MO |