Big 12 rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/1 | H | S Dakota St (8-3) | [FCS:MVFC] | W | 31-17 | |
| 9/8 | H | Rice (6-6) | [G5:CUSA] | L | 24-25 | |
| 9/15 | H | TCU (7-5) | [P4:Big 12] | L | 6-20 | |
| 9/22 | A | N Illinois (12-1) | [G5:MAC] | L | 23-30 | |
| 10/6 | A | Kansas St (11-1) | [P4:Big 12] | L | 16-56 | |
| 10/13 | H | Oklahoma St (7-5) | [P4:Big 12] | L | 14-20 | |
| 10/20 | A | Oklahoma (10-2) | [P4:Big 12] | L | 7-52 | |
| 10/27 | H | Texas (8-4) | [P4:Big 12] | L | 17-21 | |
| 11/3 | A | Baylor (7-5) | [P4:Big 12] | L | 14-41 | |
| 11/10 | A | Texas Tech (7-5) | [P4:Big 12] | L | 34-41 | |
| 11/17 | H | Iowa State (6-6) | [P4:Big 12] | L | 23-51 | |
| 12/1 | A | West Virginia (7-5) | [P4:Big 12] | L | 10-59 |