Big 12 rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 8/29 | H | Lindenwood (5-7) | [FCS:OVC] | W | 48-3 | |
| 9/7 | A | Illinois (9-3) | [P4:Big Ten] | L | 17-23 | |
| 9/13 | H | UNLV (10-3) | [G5:MWC] | L | 20-23 | |
| 9/21 | A | West Virginia (6-6) | [P4:Big 12] | L | 28-32 | |
| 9/28 | H | TCU (8-4) | [P4:Big 12] | L | 27-38 | |
| 10/5 | A | Arizona St (11-2) | [P4:Big 12] | L | 31-35 | |
| 10/19 | H | Houston (4-8) | [P4:Big 12] | W | 42-14 | |
| 10/26 | A | Kansas St (8-4) | [P4:Big 12] | L | 27-29 | |
| 11/9 | H | Iowa State (10-3) | [P4:Big 12] | W | 45-36 | |
| 11/16 | A | BYU (10-2) | [P4:Big 12] | W | 17-13 | |
| 11/23 | H | Colorado (9-3) | [P4:Big 12] | W | 37-21 | |
| 11/30 | A | Baylor (8-4) | [P4:Big 12] | L | 17-45 |