Big 12 rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/6 | H | SE Missouri (5-7) | [FCS:OVC] | W | 34-28 | |
| 9/13 | A | Duke (9-3) | [P4:ACC] | L | 3-41 | |
| 9/20 | H | C Michigan (7-5) | [G5:MAC] | W | 24-10 | |
| 9/27 | H | Texas (6-6) | [P4:Big 12] | L | 0-23 | |
| 10/4 | A | West Virginia (7-5) | [P4:Big 12] | L | 14-33 | |
| 10/11 | H | Oklahoma St (6-6) | [P4:Big 12] | L | 20-27 | |
| 10/18 | A | Texas Tech (4-8) | [P4:Big 12] | L | 21-34 | |
| 11/1 | A | Baylor (11-1) | [P4:Big 12] | L | 14-60 | |
| 11/8 | H | Iowa State (2-10) | [P4:Big 12] | W | 34-14 | |
| 11/15 | H | TCU (11-1) | [P4:Big 12] | L | 30-34 | |
| 11/22 | A | Oklahoma (8-4) | [P4:Big 12] | L | 7-44 | |
| 11/29 | A | Kansas St (9-3) | [P4:Big 12] | L | 13-51 |