Big Ten rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 8/31 | H | Ohio State (11-2) | [P4:Big Ten] | L | 21-49 | |
| 9/9 | A | Virginia (6-6) | [P4:ACC] | W | 34-17 | |
| 9/16 | H | FIU (8-4) | [G5:CUSA] | canceled | ||
| 9/23 | H | GA Southern (2-10) | [G5:Sun Belt] | W | 52-17 | |
| 9/30 | A | Penn State (10-2) | [P4:Big Ten] | L | 14-45 | |
| 10/7 | H | Charleston So (6-5) | [FCS:BSOU] | W | 27-0 | |
| 10/14 | H | Michigan (8-4) | [P4:Big Ten] | L | 20-27 | |
| 10/21 | A | Michigan St (9-3) | [P4:Big Ten] | L | 9-17 | |
| 10/28 | A | Maryland (4-8) | [P4:Big Ten] | L | 39-42 | |
| 11/4 | H | Wisconsin (12-1) | [P4:Big Ten] | L | 17-45 | |
| 11/11 | A | Illinois (2-10) | [P4:Big Ten] | W | 24-14 | |
| 11/18 | H | Rutgers (4-8) | [P4:Big Ten] | W | 41-0 | |
| 11/25 | A | Purdue (6-6) | [P4:Big Ten] | L | 24-31 |