Big Ten rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/6 | A | Marshall (9-3) | [G5:CUSA] | L | 31-41 | |
| 9/12 | H | Indiana St (5-6) | [FCS:MVFC] | W | 38-14 | |
| 9/19 | H | Virginia Tech (6-6) | [P4:ACC] | L | 24-51 | |
| 9/26 | H | Bowling Green (10-3) | [G5:MAC] | L | 28-35 | |
| 10/3 | A | Michigan St (12-1) | [P4:Big Ten] | L | 21-24 | |
| 10/10 | H | Minnesota (5-7) | [P4:Big Ten] | L | 13-41 | |
| 10/17 | A | Wisconsin (9-3) | [P4:Big Ten] | L | 7-24 | |
| 10/31 | H | Nebraska (5-7) | [P4:Big Ten] | W | 55-45 | |
| 11/7 | H | Illinois (5-7) | [P4:Big Ten] | L | 14-48 | |
| 11/14 | A | Northwestern (10-2) | [P4:Big Ten] | L | 14-21 | |
| 11/21 | A | Iowa (12-1) | [P4:Big Ten] | L | 20-40 | |
| 11/28 | H | Indiana (6-6) | [P4:Big Ten] | L | 36-54 |