Big Ten rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/3 | H | E Kentucky (5-6) | [FCS:OVC] | W | 19-13 | |
| 9/12 | H | W Michigan (5-7) | [G5:MAC] | W | 23-19 | |
| 9/19 | A | Akron (3-9) | [G5:MAC] | W | 38-21 | |
| 9/26 | A | Michigan (5-7) | [P4:Big Ten] | L | 33-36 | |
| 10/3 | H | Ohio State (10-2) | [P4:Big Ten] | L | 14-33 | |
| 10/10 | A | Virginia (3-9) | [P4:ACC] | L | 7-47 | |
| 10/17 | H | Illinois (3-9) | [P4:Big Ten] | W | 27-14 | |
| 10/24 | A | Northwestern (8-4) | [P4:Big Ten] | L | 28-29 | |
| 10/31 | A | Iowa (10-2) | [P4:Big Ten] | L | 24-42 | |
| 11/7 | H | Wisconsin (9-3) | [P4:Big Ten] | L | 28-31 | |
| 11/14 | A | Penn State (10-2) | [P4:Big Ten] | L | 20-31 | |
| 11/21 | H | Purdue (5-7) | [P4:Big Ten] | L | 21-38 |