Big Ten rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/2 | H | Towson (1-10) | [FCS:CAA] | W | 51-17 | |
| 9/18 | A | Western KY (2-10) | [G5:Sun Belt] | W | 38-21 | |
| 9/25 | H | Akron (1-11) | [G5:MAC] | W | 35-20 | |
| 10/2 | H | Michigan (7-5) | [P4:Big Ten] | L | 35-42 | |
| 10/9 | A | Ohio State (11-1) | [P4:Big Ten] | L | 10-38 | |
| 10/16 | H | Arkansas St (4-8) | [G5:Sun Belt] | W | 36-34 | |
| 10/23 | A | Illinois (6-6) | [P4:Big Ten] | L | 13-43 | |
| 10/30 | H | Northwestern (7-5) | [P4:Big Ten] | L | 17-20 | |
| 11/6 | H | Iowa (7-5) | [P4:Big Ten] | L | 13-18 | |
| 11/13 | A | Wisconsin (11-1) | [P4:Big Ten] | L | 20-83 | |
| 11/20 | N | Penn State (7-5) | [P4:Big Ten] | L | 24-41 | AT LANDOVER MD |
| 11/27 | A | Purdue (4-8) | [P4:Big Ten] | W | 34-31 |