Big Ten rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 8/31 | A | Cincinnati (9-3) | [P4:AAC] | L | 7-42 | |
| 9/7 | H | Indiana St (1-11) | [FCS:MVFC] | W | 20-14 | |
| 9/14 | H | Notre Dame (8-4) | [P4:Ind] | L | 24-31 | |
| 9/21 | A | Wisconsin (9-3) | [P4:Big Ten] | L | 10-41 | |
| 9/28 | H | N Illinois (12-1) | [G5:MAC] | L | 24-55 | |
| 10/12 | H | Nebraska (8-4) | [P4:Big Ten] | L | 7-44 | |
| 10/19 | A | Michigan St (12-1) | [P4:Big Ten] | L | 0-14 | |
| 11/2 | H | Ohio State (12-1) | [P4:Big Ten] | L | 0-56 | |
| 11/9 | H | Iowa (8-4) | [P4:Big Ten] | L | 14-38 | |
| 11/16 | A | Penn State (7-5) | [P4:Big Ten] | L | 21-45 | |
| 11/23 | H | Illinois (4-8) | [P4:Big Ten] | L | 16-20 | |
| 11/30 | A | Indiana (5-7) | [P4:Big Ten] | L | 36-56 |