Big Ten rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 8/31 | H | Indiana St (4-8) | [FCS:MVFC] | W | 49-0 | |
| 9/14 | H | Notre Dame (11-1) | [P4:Ind] | L | 7-66 | |
| 9/21 | A | Oregon St (5-7) | [G5:Pac-12] | L | 21-38 | |
| 9/28 | H | Nebraska (6-6) | [P4:Big Ten] | L | 10-28 | |
| 10/5 | A | Wisconsin (5-7) | [P4:Big Ten] | L | 6-52 | |
| 10/12 | A | Illinois (9-3) | [P4:Big Ten] | L | 49-50 | |
| 10/18 | H | Oregon (13-0) | [P4:Big Ten] | L | 0-35 | |
| 11/2 | H | Northwestern (4-8) | [P4:Big Ten] | L | 20-26 | |
| 11/9 | A | Ohio State (10-2) | [P4:Big Ten] | L | 0-45 | |
| 11/16 | H | Penn State (11-2) | [P4:Big Ten] | L | 10-49 | |
| 11/22 | A | Michigan St (5-7) | [P4:Big Ten] | L | 17-24 | |
| 11/30 | A | Indiana (11-1) | [P4:Big Ten] | L | 0-66 |