Big Ten rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/4 | A | Notre Dame (7-5) | [P4:Ind] | L | 12-23 | |
| 9/11 | H | W Illinois (7-4) | [FCS:MVFC] | W | 31-21 | |
| 9/18 | H | Ball State (4-8) | [G5:MAC] | W | 24-13 | |
| 9/25 | H | Toledo (8-4) | [G5:MAC] | L | 20-31 | |
| 10/9 | A | Northwestern (7-5) | [P4:Big Ten] | W | 20-17 | |
| 10/16 | H | Minnesota (3-9) | [P4:Big Ten] | W | 28-17 | |
| 10/23 | A | Ohio State (11-1) | [P4:Big Ten] | L | 0-49 | |
| 10/30 | A | Illinois (6-6) | [P4:Big Ten] | L | 10-44 | |
| 11/6 | H | Wisconsin (11-1) | [P4:Big Ten] | L | 13-34 | |
| 11/13 | H | Michigan (7-5) | [P4:Big Ten] | L | 16-27 | |
| 11/20 | A | Michigan St (11-1) | [P4:Big Ten] | L | 31-35 | |
| 11/27 | H | Indiana (5-7) | [P4:Big Ten] | L | 31-34 |