Big 12 rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/4 | H | Western KY (9-2) | [FCS:MVFC] | W | 27-13 | |
| 9/11 | H | Fresno St (8-3) | [G5:WAC] | L | 21-45 | |
| 9/18 | H | Louisiana (4-7) | [G5:Sun Belt] | W | 40-20 | |
| 10/2 | A | Texas A&M (7-4) | [P4:Big 12] | L | 30-42 | |
| 10/9 | A | Kansas (4-7) | [P4:Big 12] | L | 28-31 | |
| 10/16 | H | Oklahoma (12-0) | [P4:Big 12] | L | 21-31 | |
| 10/23 | H | Nebraska (5-6) | [P4:Big 12] | W | 45-21 | |
| 10/30 | H | Texas Tech (7-4) | [P4:Big 12] | L | 25-35 | |
| 11/6 | A | Missouri (5-6) | [P4:Big 12] | W | 35-24 | |
| 11/13 | A | Colorado (7-5) | [P4:Big 12] | L | 31-38 | |
| 11/20 | H | Iowa State (6-5) | [P4:Big 12] | L | 23-37 |