Big 12 rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/5 | H | UMass (5-6) | [FCS:CAA] | W | 21-17 | |
| 9/12 | A | Louisiana (6-6) | [G5:Sun Belt] | L | 15-17 | |
| 9/19 | A | UCLA (6-6) | [P4:Pac-12] | L | 9-23 | |
| 9/26 | H | Tennessee Tech (6-5) | [FCS:OVC] | W | 49-7 | |
| 10/3 | A | Iowa State (6-6) | [P4:Big 12] | W | 24-23 | AT KANSAS CITY MO |
| 10/10 | A | Texas Tech (8-4) | [P4:Big 12] | L | 14-66 | |
| 10/17 | H | Texas A&M (6-6) | [P4:Big 12] | W | 62-14 | |
| 10/24 | H | Colorado (3-9) | [P4:Big 12] | W | 20-6 | |
| 10/31 | A | Oklahoma (7-5) | [P4:Big 12] | L | 30-42 | |
| 11/7 | H | Kansas (5-7) | [P4:Big 12] | W | 17-10 | |
| 11/14 | H | Missouri (8-4) | [P4:Big 12] | L | 12-38 | |
| 11/21 | A | Nebraska (9-4) | [P4:Big 12] | L | 3-17 |