Big 12 rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 8/30 | H | North Texas (1-11) | [G5:Sun Belt] | W | 45-6 | |
| 9/6 | H | Montana St (7-5) | [FCS:BSKY] | W | 69-10 | |
| 9/17 | A | Louisville (5-7) | [P4:Big East] | L | 29-38 | |
| 9/27 | H | Louisiana (6-6) | [G5:Sun Belt] | W | 45-37 | |
| 10/4 | H | Texas Tech (11-1) | [P4:Big 12] | L | 28-58 | |
| 10/11 | A | Texas A&M (4-8) | [P4:Big 12] | W | 44-30 | |
| 10/18 | A | Colorado (5-7) | [P4:Big 12] | L | 13-14 | |
| 10/25 | H | Oklahoma (12-1) | [P4:Big 12] | L | 35-58 | |
| 11/1 | A | Kansas (7-5) | [P4:Big 12] | L | 21-52 | |
| 11/8 | A | Missouri (9-4) | [P4:Big 12] | L | 24-41 | |
| 11/15 | H | Nebraska (8-4) | [P4:Big 12] | L | 28-56 | |
| 11/22 | H | Iowa State (2-10) | [P4:Big 12] | W | 38-30 |