Big 12 rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/3 | H | FIU (5-6) | [G5:Sun Belt] | W | 35-21 | |
| 9/10 | A | Marshall (4-7) | [G5:CUSA] | W | 21-19 | |
| 9/24 | H | North Texas (2-9) | [G5:Sun Belt] | W | 54-7 | |
| 10/1 | A | Oklahoma (7-4) | [P4:Big 12] | L | 21-43 | |
| 10/8 | H | Kansas (6-5) | [P4:Big 12] | W | 12-3 | |
| 10/15 | A | Texas Tech (9-2) | [P4:Big 12] | L | 20-59 | |
| 10/22 | H | Texas A&M (5-6) | [P4:Big 12] | L | 28-30 | |
| 10/29 | H | Colorado (7-5) | [P4:Big 12] | L | 20-23 | |
| 11/5 | A | Iowa State (7-4) | [P4:Big 12] | L | 17-45 | |
| 11/12 | A | Nebraska (7-4) | [P4:Big 12] | L | 25-27 | |
| 11/19 | H | Missouri (6-5) | [P4:Big 12] | W | 36-28 |