Big 12 rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/2 | H | UTSA (8-4) | [G5:AAC] | W | 17-14 | |
| 9/9 | A | Rice (6-6) | [G5:AAC] | L | 41-43 | |
| 9/16 | H | TCU (5-7) | [P4:Big 12] | L | 13-36 | |
| 9/23 | H | Sam Houston (3-9) | [G5:CUSA] | W | 38-7 | |
| 9/30 | A | Texas Tech (6-6) | [P4:Big 12] | L | 28-49 | |
| 10/12 | H | West Virginia (8-4) | [P4:Big 12] | W | 41-39 | |
| 10/21 | H | Texas (12-1) | [P4:Big 12] | L | 24-31 | |
| 10/28 | A | Kansas St (8-4) | [P4:Big 12] | L | 0-41 | |
| 11/4 | A | Baylor (3-9) | [P4:Big 12] | W | 25-24 | |
| 11/11 | H | Cincinnati (3-9) | [P4:Big 12] | L | 14-24 | |
| 11/18 | H | Oklahoma St (9-4) | [P4:Big 12] | L | 30-43 | |
| 11/25 | A | UCF (6-6) | [P4:Big 12] | L | 13-27 |