Conference USA rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/5 | A | Rice (3-8) | [G5:WAC] | L | 7-10 | |
| 9/11 | A | Oklahoma (12-0) | [P4:Big 12] | L | 13-63 | |
| 9/18 | H | Army (2-9) | [G5:CUSA] | W | 35-21 | |
| 9/23 | H | Miami (8-3) | [P4:ACC] | L | 13-38 | AT RELIANT STADIUM |
| 10/2 | A | Memphis (8-3) | [G5:CUSA] | L | 14-41 | |
| 10/7 | A | Southern Miss (6-5) | [G5:CUSA] | L | 29-35 | |
| 10/23 | A | TCU (5-6) | [G5:CUSA] | L | 27-34 | |
| 10/30 | H | Tulane (5-6) | [G5:CUSA] | W | 24-3 | |
| 11/6 | H | East Carolina (2-9) | [G5:CUSA] | W | 34-24 | |
| 11/13 | A | UAB (7-4) | [G5:CUSA] | L | 7-20 | |
| 11/20 | H | Louisville (10-1) | [G5:CUSA] | L | 27-65 |