Big East rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/4 | A | Fresno St (8-4) | [G5:WAC] | L | 14-28 | |
| 9/11 | H | Indiana St (6-5) | [FCS:MVFC] | W | 40-7 | |
| 9/16 | A | NC State (8-4) | [P4:ACC] | L | 19-30 | |
| 9/25 | H | Oklahoma (11-2) | [P4:Big 12] | L | 29-31 | |
| 10/9 | H | Miami OH (9-4) | [G5:MAC] | W | 45-3 | |
| 10/15 | A | Louisville (6-6) | [P4:Big East] | W | 35-27 | |
| 10/22 | H | South Florida (7-5) | [P4:Big East] | L | 30-38 | |
| 10/30 | H | Syracuse (7-5) | [P4:Big East] | L | 7-31 | |
| 11/13 | A | West Virginia (9-3) | [P4:Big East] | L | 10-37 | |
| 11/20 | H | Rutgers (4-8) | [P4:Big East] | W | 69-38 | |
| 11/27 | A | UConn (8-4) | [P4:Big East] | L | 17-38 | |
| 12/4 | H | Pitt (7-5) | [P4:Big East] | L | 10-28 |