Big 12 rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/3 | A | SMU (5-6) | [G5:CUSA] | W | 28-23 | |
| 9/10 | H | Samford (5-6) | [FCS:OVC] | W | 48-14 | |
| 9/17 | A | Army (4-7) | [G5:Ind] | W | 20-10 | |
| 10/1 | A | Texas A&M (5-6) | [P4:Big 12] | L | 13-16 | |
| 10/8 | A | Iowa State (7-4) | [P4:Big 12] | W | 23-13 | |
| 10/15 | H | Nebraska (7-4) | [P4:Big 12] | L | 14-23 | |
| 10/22 | A | Oklahoma (7-4) | [P4:Big 12] | L | 30-37 | |
| 10/29 | H | Texas Tech (9-2) | [P4:Big 12] | L | 0-28 | |
| 11/5 | H | Texas (12-0) | [P4:Big 12] | L | 0-62 | |
| 11/12 | A | Missouri (6-5) | [P4:Big 12] | L | 16-31 | |
| 11/19 | H | Oklahoma St (4-7) | [P4:Big 12] | W | 44-34 |