Big 12 rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/4 | A | UAB (7-4) | [G5:CUSA] | L | 14-56 | |
| 9/11 | H | Texas St (5-6) | [FCS:LAND] | W | 24-17 | |
| 9/25 | H | North Texas (7-4) | [G5:Sun Belt] | W | 37-14 | |
| 10/2 | A | Texas (10-1) | [P4:Big 12] | L | 14-44 | |
| 10/9 | H | Missouri (5-6) | [P4:Big 12] | L | 10-30 | |
| 10/16 | A | Nebraska (5-6) | [P4:Big 12] | L | 27-59 | |
| 10/23 | H | Iowa State (6-5) | [P4:Big 12] | L | 25-26 | |
| 10/30 | H | Texas A&M (7-4) | [P4:Big 12] | W | 35-34 | |
| 11/6 | A | Texas Tech (7-4) | [P4:Big 12] | L | 17-42 | |
| 11/13 | A | Oklahoma St (7-4) | [P4:Big 12] | L | 21-49 | |
| 11/20 | H | Oklahoma (12-0) | [P4:Big 12] | L | 0-35 |