Big 12 rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/3 | A | Clemson (7-4) | [P4:ACC] | L | 24-25 | |
| 9/17 | H | SMU (5-6) | [G5:CUSA] | W | 66-8 | |
| 9/22 | H | Texas St (9-2) | [FCS:LAND] | W | 44-31 | |
| 10/1 | H | Baylor (5-6) | [P4:Big 12] | W | 16-13 | |
| 10/8 | A | Colorado (7-5) | [P4:Big 12] | L | 20-41 | |
| 10/15 | H | Oklahoma St (4-7) | [P4:Big 12] | W | 62-23 | |
| 10/22 | A | Kansas St (5-6) | [P4:Big 12] | W | 30-28 | |
| 10/29 | H | Iowa State (7-4) | [P4:Big 12] | L | 14-42 | |
| 11/5 | A | Texas Tech (9-2) | [P4:Big 12] | L | 17-56 | |
| 11/12 | A | Oklahoma (7-4) | [P4:Big 12] | L | 30-36 | |
| 11/25 | H | Texas (12-0) | [P4:Big 12] | L | 29-40 |