ACC rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/2 | H | Wofford (2-9) | [FCS:SOUTH] | W | 45-7 | |
| 9/9 | H | Cincinnati (3-9) | [P4:Big 12] | L | 21-27 | |
| 9/16 | A | West Virginia (8-4) | [P4:Big 12] | L | 6-17 | |
| 9/23 | H | North Carolina (8-4) | [P4:ACC] | L | 24-41 | |
| 9/30 | A | Virginia Tech (6-6) | [P4:ACC] | L | 21-38 | |
| 10/14 | H | Louisville (10-3) | [P4:ACC] | W | 38-21 | |
| 10/21 | A | Wake Forest (4-8) | [P4:ACC] | L | 17-21 | |
| 10/28 | A | Notre Dame (9-3) | [P4:Ind] | L | 7-58 | |
| 11/4 | H | Florida St (13-0) | [P4:ACC] | L | 7-24 | |
| 11/11 | N | Syracuse (6-6) | [P4:ACC] | L | 13-28 | |
| 11/16 | H | Boston College (6-6) | [P4:ACC] | W | 24-16 | |
| 11/25 | A | Duke (7-5) | [P4:ACC] | L | 19-30 |