ACC rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/12 | H | Austin Peay (0-3) | [FCS:OVC] | W | 55-0 | |
| 9/19 | H | Syracuse (1-10) | [P4:ACC] | W | 21-10 | |
| 9/26 | H | Louisville (4-7) | [P4:ACC] | W | 23-20 | |
| 10/3 | H | NC State (8-3) | [P4:ACC] | L | 29-30 | |
| 10/10 | A | Boston College (6-5) | [P4:ACC] | L | 30-31 | |
| 10/17 | A | Miami (8-2) | [P4:ACC] | L | 19-31 | |
| 10/24 | H | Notre Dame (10-1) | [P4:ACC] | L | 3-45 | |
| 11/7 | A | Florida St (3-6) | [P4:ACC] | W | 41-17 | |
| 11/14 | A | Georgia Tech (3-7) | [P4:ACC] | postponed | ||
| 11/21 | H | Virginia Tech (5-6) | [P4:ACC] | W | 47-14 | |
| 11/28 | A | Clemson (10-1) | [P4:ACC] | L | 17-52 | |
| 12/10 | A | Georgia Tech (3-7) | [P4:ACC] | W | 34-20 |