Big 12 rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 8/30 | H | Northern Iowa (9-2) | [FCS:MVFC] | W | 17-10 | |
| 9/6 | H | Ohio (2-10) | [G5:MAC] | W | 48-20 | |
| 9/13 | H | Iowa (9-3) | [P4:Big Ten] | L | 21-40 | |
| 9/27 | A | N Illinois (10-2) | [G5:MAC] | L | 16-24 | |
| 10/4 | H | Oklahoma (12-1) | [P4:Big 12] | L | 7-53 | |
| 10/11 | A | Texas Tech (7-5) | [P4:Big 12] | L | 21-52 | |
| 10/18 | H | Texas (10-2) | [P4:Big 12] | L | 19-40 | |
| 10/25 | A | Nebraska (9-3) | [P4:Big 12] | L | 0-28 | |
| 11/8 | H | Kansas St (11-3) | [P4:Big 12] | L | 0-45 | |
| 11/15 | H | Colorado (5-7) | [P4:Big 12] | L | 10-44 | |
| 11/22 | A | Kansas (6-6) | [P4:Big 12] | L | 7-36 | |
| 11/29 | A | Missouri (8-4) | [P4:Big 12] | L | 7-45 |