Big 12 rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 8/30 | H | Kent State (3-9) | [G5:MAC] | L | 14-23 | |
| 9/8 | H | Northern Iowa (11-0) | [FCS:MVFC] | L | 13-24 | |
| 9/15 | H | Iowa (6-6) | [P4:Big Ten] | W | 15-13 | |
| 9/22 | A | Toledo (5-7) | [G5:MAC] | L | 35-36 | |
| 9/29 | A | Nebraska (5-7) | [P4:Big 12] | L | 17-35 | |
| 10/6 | A | Texas Tech (8-4) | [P4:Big 12] | L | 17-42 | |
| 10/13 | H | Texas (9-3) | [P4:Big 12] | L | 3-56 | |
| 10/20 | H | Oklahoma (11-2) | [P4:Big 12] | L | 7-17 | |
| 10/27 | A | Missouri (11-2) | [P4:Big 12] | L | 28-42 | |
| 11/3 | H | Kansas St (5-7) | [P4:Big 12] | W | 31-20 | |
| 11/10 | H | Colorado (6-6) | [P4:Big 12] | W | 31-28 | |
| 11/17 | A | Kansas (11-1) | [P4:Big 12] | L | 7-45 |