Big 12 rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/3 | H | SE Missouri (9-2) | [FCS:OVC] | W | 42-10 | |
| 9/10 | A | Iowa (7-5) | [P4:Big Ten] | W | 10-7 | |
| 9/17 | H | Ohio (9-4) | [G5:MAC] | W | 43-10 | |
| 9/24 | H | Baylor (6-6) | [P4:Big 12] | L | 24-31 | |
| 10/1 | A | Kansas (6-6) | [P4:Big 12] | L | 11-14 | |
| 10/8 | H | Kansas St (10-3) | [P4:Big 12] | L | 9-10 | |
| 10/15 | A | Texas (8-4) | [P4:Big 12] | L | 21-24 | |
| 10/29 | H | Oklahoma (6-6) | [P4:Big 12] | L | 13-27 | |
| 11/5 | H | West Virginia (5-7) | [P4:Big 12] | W | 31-14 | |
| 11/12 | A | Oklahoma St (7-5) | [P4:Big 12] | L | 14-20 | |
| 11/19 | H | Texas Tech (7-5) | [P4:Big 12] | L | 10-14 | |
| 11/26 | A | TCU (12-1) | [P4:Big 12] | L | 14-62 |