Big 12 rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/4 | H | Duquesne (7-3) | [FCS:NEAST] | W | 45-3 | |
| 9/11 | H | California (5-7) | [P4:Pac-12] | W | 34-32 | |
| 9/25 | H | SMU (8-4) | [G5:AAC] | L | 34-42 | |
| 10/2 | H | Texas (5-7) | [P4:Big 12] | L | 27-32 | |
| 10/9 | A | Texas Tech (6-6) | [P4:Big 12] | W | 52-31 | |
| 10/16 | A | Oklahoma (10-2) | [P4:Big 12] | L | 31-52 | |
| 10/23 | H | West Virginia (6-6) | [P4:Big 12] | L | 17-29 | |
| 10/30 | A | Kansas St (7-5) | [P4:Big 12] | L | 12-31 | |
| 11/6 | H | Baylor (11-2) | [P4:Big 12] | W | 30-28 | |
| 11/13 | A | Oklahoma St (11-2) | [P4:Big 12] | L | 17-63 | |
| 11/20 | H | Kansas (2-10) | [P4:Big 12] | W | 31-28 | |
| 11/26 | A | Iowa State (7-5) | [P4:Big 12] | L | 14-48 |