Big 12 rankings · National FBS rankings · All teams
| Date | H/A | Opponent | Tier:Conf | Result | Score | Notes |
|---|---|---|---|---|---|---|
| 9/4 | H | Louisiana (12-1) | [G5:Sun Belt] | W | 38-18 | |
| 9/11 | A | Arkansas (8-4) | [P4:SEC] | L | 21-40 | |
| 9/18 | H | Rice (4-8) | [G5:CUSA] | W | 58-0 | |
| 9/25 | H | Texas Tech (6-6) | [P4:Big 12] | W | 70-35 | |
| 10/2 | A | TCU (5-7) | [P4:Big 12] | W | 32-27 | |
| 10/9 | N | Oklahoma (10-2) | [P4:Big 12] | L | 48-55 | |
| 10/16 | H | Oklahoma St (11-2) | [P4:Big 12] | L | 24-32 | |
| 10/30 | A | Baylor (11-2) | [P4:Big 12] | L | 24-31 | |
| 11/6 | A | Iowa State (7-5) | [P4:Big 12] | L | 7-30 | |
| 11/13 | H | Kansas (2-10) | [P4:Big 12] | L | 56-57 | |
| 11/20 | A | West Virginia (6-6) | [P4:Big 12] | L | 23-31 | |
| 11/26 | H | Kansas St (7-5) | [P4:Big 12] | W | 22-17 |